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The method of therapy consists of the action of a light-sensitive drug previously introduced into the body and the application of a certain wavelength of light to the affected area.
Photodynamic Therapy – Targeted Treatment for Cancer and Skin Conditions
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Photodynamic therapy (PDT) - this method of therapy consists in the action of a light-sensitive drug previously introduced into the body and the supply of a certain wavelength of light to the sore spot. It is often the method of choice of treatment, especially in oncological practice, in particular when it comes to aesthetics. Of course, these are inoperable cases of the otolaryngology department, when very traumatic operations are unacceptable or simply impossible.
- In our clinic, along with PDT, it is possible to conduct fluorescent diagnostics - that is, before the start of the session, the diagnostics themselves are carried out, where diseased cells are detected under the violet color in the form of crimson spots, upon completion of therapy, a repeated diagnostic control - if the spots are still there, you can continue to treat them, if they are absent, then the therapy is complete. Complete confidence.
Advantages
- Application in “inconvenient” areas of the tumor when surgical treatment is impossible due to anatomical features or may lead to severe cosmetic consequences, when anesthesia is contraindicated.
- Frequency. The PDT procedure is performed once in 95% of skin cancer cases.
- No toxicity.
- One-stage ultraviolet diagnostics allows monitoring the quality of the therapy process, i.e. helps the doctor determine the need for additional time of exposure to the focus of a particular tumor, or identify suspicious areas accumulating a photosensitizer in the form of “raspberry spots”.
- Second-generation drugs of the chlorin E6 group registered in the Republic of Kazakhstan are used as photosensitizers.
How does this work?
1
The medicine (photosensitizer) is administered intravenously several hours in advance, and there are also forms in the form of a gel if this concerns the external treatment area. After which the drug introduced into the body is selectively or selectively collected where there is a diseased focus, there its saturated accumulation occurs.
2
Light source (photodynamic therapy device) - looks like a flashlight, optical fiber in diameter of several millimeters, it depends on what and in what part needs to be treated. In advance, the doctor calculates the power, energy and time of exposure of infrared light to the diseased area, on average, the PDT procedure can take from 5 to 20 minutes.
3
Under the influence of light, many biochemical reactions occur; under the influence of infrared light, singlet oxygen is produced, and then the cancerous (sick, atypical, dysplastic) cell is destroyed.
4
The regeneration process is when the place of diseased cell tissue is replaced by new, fresh cells of collagen, elastin and epithelium.
History.
In 1903, the Nobel Prize was awarded to Niels Roberge Finsen (a Danish scientist, physiotherapist) for his achievements in the treatment of tuberculous lupus, and in the same year, skin cancer was first treated in this way.
In 1924, the era of porphyrins began - when it became possible to diagnose inflamed cells in addition to treatment.
The success that photodynamic technology has today is due to the period of the 40-80s of the last century, when many fundamental studies were argued on the development of both photosensitizers and light therapy technology. Today, there are about 6 generations of photosensitizers. Work on improving photodynamic therapy continues today.
Contraindications to the use of photodynamic therapy:
Contraindications to PDT can be absolute and relative.
Absolute contraindications:
- cardiovascular and respiratory failure;
- decompensated liver and kidney diseases;
- porphyria;
- systemic lupus erythematosus;
- cachexia;
- pregnancy;
Relative contraindications:
- allergic reaction or individual intolerance to the drug;
- distant and regional tumor metastases;
- the presence of concomitant severe diseases.
Indications for the use of photodynamic therapy in gynecology:
PDT can be used independently as an organ-preserving method of radical treatment, and as a combination treatment for the following pathologies:
- endometriosis of the cervix;
- HPV-associated diseases (condylomas of the cervix, vagina and vulva);
- leukoplakia of the cervix;
- dysplasia of the cervix of grades I-III;
- carcinoma in situ of the cervix;
- cervical cancer;
- lichen sclerosus;
- vulvar leukoplakia;
- vulvar dysplasia VIN I-III;
- vulvar carcinoma in situ;
- vulvar cancer;
- vaginal dysplasia VaIN I-III;
- adenomyosis;
- complex endometrial hyperplasia.
In 1903, the Nobel Prize was awarded to Niels Roberge Finsen (a Danish scientist, physiotherapist) for his achievements in the treatment of tuberculous lupus, and in the same year, skin cancer was first treated in this way.
In 1924, the era of porphyrins began - when it became possible to diagnose inflamed cells in addition to treatment.
The success that photodynamic technology has today is due to the period of the 40-80s of the last century, when many fundamental studies were argued on the development of both photosensitizers and light therapy technology. Today, there are about 6 generations of photosensitizers. Work on improving photodynamic therapy continues today.
Contraindications to the use of photodynamic therapy:
Contraindications to PDT can be absolute and relative.
Absolute contraindications:
- cardiovascular and respiratory failure;
- decompensated liver and kidney diseases;
- porphyria;
- systemic lupus erythematosus;
- cachexia;
- pregnancy;
Relative contraindications:
- allergic reaction or individual intolerance to the drug;
- distant and regional tumor metastases;
- the presence of concomitant severe diseases.
Indications for the use of photodynamic therapy in gynecology:
PDT can be used independently as an organ-preserving method of radical treatment, and as a combination treatment for the following pathologies:
- endometriosis of the cervix;
- HPV-associated diseases (condylomas of the cervix, vagina and vulva);
- leukoplakia of the cervix;
- dysplasia of the cervix of grades I-III;
- carcinoma in situ of the cervix;
- cervical cancer;
- lichen sclerosus;
- vulvar leukoplakia;
- vulvar dysplasia VIN I-III;
- vulvar carcinoma in situ;
- vulvar cancer;
- vaginal dysplasia VaIN I-III;
- adenomyosis;
- complex endometrial hyperplasia.
Our contacts
+7 777 825 18 18
oncobiomedical@gmail.com
Almaty, Abdulla Rozybakiev street, 33A
oncobiomedical@gmail.com
Almaty, Abdulla Rozybakiev street, 33A
